I've been loading my pack .44 with 320 casts for a few years now, but then just last summer decided to go a little smaller and faster, with 300grn JSP's, in wood there really isn't much difference in penetration, and I would trust them for protection, which is what I usually use them for.
When Im plinking I will usually use 240 grn JHP, which have much less penetration compared to the 300grn JSP. So far Im a fan of the JSP's, I actually started carrying a 300grn JSP in my .454 also, though I still do bring the 335grn casts... I guess that all depends on my mood