I have an older NEF .444 with laminated stock, and its a 1-hole shooter at 100yrds. when I do my part. I handload ALL my loads, and I love the gun. I wouldn't trade it for any of the 45-70's i've seen shot.
My load:
Brass: Remington
Bullet: Hornady 240grn. XTP
Powder: IMR4198, 45grns.
Primer: CCI Bench Rest, Large rifle
I also have a decent load worked up for 300grn. XTP's. But its not a 1-hole shooter.
I've shot MANY deer with my .444, and i've never lost 1 deer yet. I've also recoverd 2 bullets from deer that i've shot with that 240XTP. The expansion, and bullet retention was flawless.