I used to have a 500 S&W Encore rifle barrel (by VV). It kicked so much that I first braked it, and then sold it because it still kicked too much!
As advice, my first load was with the Hornady 350 XTP bullet. I shot a deer with this load at about 25 yards. The bullet completely shattered into tiny pieces and barely penetrated. The deer only took about 2 steps, but the bullet wasn't up to the extra velocity of the rifle length barrel. I then switched to the Barnes 275 grainer, hoping to get less recoil.
I'd suggest starting with the Barnes 275 grain bullet because of the lesser recoil. Then if you survive that (I didn't) then try some heavier bullets.
And, to prove I'm not just a complete recoil whimp -- I have no problem with full house (unbraked) 45-70 loads in my Encore. The 500 S&W is a significant step up from that (recoil wise).
Good luck,
B. Noz.
ps -- if you want 500 S&W dies (RCBS), brass, and a handful of bullets, then pm me off line. I'll see what I have left and quote you a price.