Cougar,
Just a little food for thought.....a few years ago when Linebaugh was turning out his first five shot revolvers, a fellow named Ross Seyfried (an professional hunter in Africa) acquired one in .45 Colt. It load drove a 345 grain hard cast .452" bullet at 1550 fps. Seyfried used the revolver to kill more than one Cape Buffalo quite satisfactorily.
The full house Casull may be more than you need!! Free bore the 45 Colt throat and seat the bullet out a bit (reduces pressure with the larger space inside the brass)....you may be able to get Seyfried's buff killer without straining your Handi. Say you're only able to get 1400 fps.....okay.... how many buff will you see here in the USA?
Hmmmmm......no, I have not done this......no, I'm not a gunsmith........ yes, I've a .45 Colt Big Ruger that I load heavily.
Lobo in West Virginia