I'd say either a GP100 or a Blackhawk. Whichever action (DA or SA) you prefer. If you're to be using the hotter loads, I'd think they'd hold up better over time than the 686 would.
While a few have also mentioned using a .44, I'd opt for the .41 mag or maybe even the .357 maximum.
Another good idea would be a .357 Hunter from Ruger. I can hope.