Most of what I have read and found is that the 300rum is best with the 180-200 class bullets. But ya never know. I bet a 165 will come out screamin if it will maintain good. Most bigger cal have better down range performance with the heavier bullets. I use to be one of the ones that just looked at MV,then I learned to look at 300+ ballistics. That's where the story is told. What's the old saying- It's not how ya start, it's how ya finish.
Good luck, DM
PS- If you try the 200 AB, most have found the best accuracy between 3100 and 3200 fps with several differant powders. RL25, Retumbo, H1000 seem to be the powders where most people land.