I think the whole "Don't Shoot Anybody With A Reload" thing is a double-edged sword. I've been a reloader for a long time, and I've had a lot more trouble with factory ammo than I have with my own practice ammo. A 45ACP load blew out over the feed ramp in a 1911, I've had 357 ammo with inverted primers, some that didn't have the flash hole punched out, even bullets seated backwards and upside down. These were NOT commercial reloads, this was pricey, name-brand ammo, bought at full retail.
Having said that, Massad Ayoob has listed several instances where people were taken to task by prosecutors for using handloads, inferring that they were practicing alchemy or witchcraft by concocting "Extra deadly ammo, so deadly the factories don't even sell it....." Just because it's a stupid point doesn't mean some scumbag lawyer wouldn't try it. Personally, I'll stick with the factory loads, but you can bet I'll examine them VERY carefully before I put anything in my gun.
As for overpenetration, I'd have two separate loads,, one for defense, one for woods bumming. For two-legged predators, I'd try the 135 or 155 grain Hollow-Point loads, both are loaded pretty hot, but shouldn't overpenetrate on a chest shot.
And if you can get two BG's to line up, I say try for a double head-shot. Even if it doesn't kill the second one, it should still interrupt his train of thought!
Papajohn