I have a 17 Rem, a 220 Swift, a 243, and many larger. I don't take many of them out any more since I bought my Kimber Classic Varmint in 204 Ruger. It has yet to let me down. I have taken Coyotes out to, and slightly beyond 400 yards; and all were one shot kills. I can't say it outperforms the 22-250 or 220 Swift, but the muzzle blast, noise , and recoil is SOOOOO much more pleasant that I don't use the others much any more. And the accuracy of this rifle.......................WOW.