Any time you change anything in a load you can expect a change in the point of impact, differences in powder charges, a different powder,, changing to a different brand of bullet, even in the same weight, it's difficult to predict where a bullet is going to impact with the possible exception of bullet weight, lighter bullets almost always impact lower on the target than heavier ones. Another thing is that the changes in impact aren't limited to elevation, they often include changes in windage as well.