Personally, I like Unique better with 125g bullets. A 125g HP with 7.5g to about 8.5g with a CCI 550 primer makes a nice midrange load that'll thump a groundhog, coyote, coon, possum, or such like a hammer with very light recoil.
For maximum loads I prefer a good 158g bullet loaded with a maximum charge of Lil' Gun. You won't beat Lil' Gun for sheer velocity, and it's been very accurate for me too. It also meters like a dream. Other great powders with 140g+ bullets are H-110, 296, and AA-9.