All my rifles have fixed power (2.5X, 3X, 4X, or 6X) scopes mounted as low as possible. All my shooting (practice) is done with big game hunting in mind. Even the 223 with 6X is just a practice gun for my larger calibers.
I hunt close. In the last five years I have fired at game beyond 100 yards twice: an antelope with '06 at about 125 and a mule deer with .35 Rem. near 200 yards. Last Fall I used the .444 with Weaver K2.5 to take a 5X5 mule deer at about 65 yds., and a cow elk at less than 50 yds.
I sight everything in to be 2" high at 100 yards. I can hold on hair out to 200 yards on antelope, deer and elk with all my rifles (30-30, 35 Rem., 30-06, 35 Whelen, and .444 Marlin).