Probably not a serious issue, as I don't know of any failures. I have a Navy Arms Pietta which barrel unscrewed while shooting, but an application of Locktite solved that.
I noted the barrel steel as pretty soft when I recut the forcing cone with a Brownell's tool. The softness could result in early bore rifling wear, but with soft lead bullets, it probably won't occur in our lifetime. I shoot 45Colt in R&D cylinders in my Piettas, and have seen no splitting or damage to the forcing cone area, which, with the exposed threads, would seem vulnerable to damage with the harder, heavier cartridge loaded bullets and smokeless powder.
The soft parts that do make trouble are inside, the hand and bolt are not as hard as they should be, and particularly with a conversion cylinder made of 4140 or 4150 steel, the hand does get chewed up some. I was thinking that new, hardened steel replacement hands for both Ubertis and Piettas could have some market, to go with the Kirst and R&D cylinders. The Kirst is particularly hard on the soft Italian hands, as the rachet is like a series of chisels, cutting away at the hand nose.