Lets see, I`ve had at least one 250, Mod 20, for 52 years. In fact, started my reloading hoby with that cartridge, plus killing gobs of woodchucks! Today I`ve five, three AIs, which I shot the most. My son built one for 1k shooting last year, using JLK 108 and Burger 115 grners.
Can`t tell you how many deer we`ve killed over the years, but it`s been more than a few. Also antilope and Mule deer. No problems with either.
The ONLY complaint I have with the cartridge is that it grows, needs constant trimming, when pushed to max velocities. And thats because of the body taper in the case design. AIing it removes the problem.
I would stay with 1x10 twist, which will handle up to 120 grn spitzers.
BTB, the Model 20 was the first light weight hi-power rifle on the market...should you wish to believe Savage marketing advertizement. The rifle is indeed light, I got two.