Weatherby Accumark in .338/378, 6X15X50 Night Force scope, bi-pod, 110gr of IMR 7828 pushing a 225gr Nosler Accubond at 3210fps, and a leapold RX VI range finder with inclinemoter. 50 to 800 yards, hitting a 1 gal milk jug every shot. It took lots of time and practice to be able to do this. I think nothing of shooting a wolf at 500 yards, and this last fall I shot a Moose at 800 yards. The Moose took three steps and fell, one shot. Eventually I will work on out to 1000 yards, but again I will be hitting that milk jug at that range 100% of the time before I make that shot on a Moose. And I will probably take many Wolves at that range before I take a Moose.
NEF Handi Rifle in 30-06, Burris 3.5X10X50 w/Ballistic Plex, 165gr Sierria Boat Tail. 50 to 500 yards, no problem. Beyond 600 the bullet does not have the energy left to make a clean kill on a wolf. After having to chase two wolves down, one at 650 yards and the other at 700 yards, I no longer take shots beyond 500 yards with the 30-06. Hitting them is no problem, but like I said the bullet lacks the energy to make clean kills. That's why I went to a the Weatherby.
Wind? I usually hunt early in the mornings when there is no wind.
My favorite scnario, 0 degree, one hour after sunrise, crawl over a ridge and find a pack of wolves on a Moose kill. 500 to 600 yard shot. Determine the Alpha Male, wait till he is the farthest away and take the shot. The first thing the others hear is the bullet thump. They run from that loud close sound, straight towards me. At around 100 yards the Aplha Female will stop and look back to see why the Male is not following, I take my second shot. Again the rest of the pack run from the sound of the bullet striking, coming my way. Then wait till the pack is as close as I want them to be. After the third or forth shot they place the sound of the rifle with the strikes and scatter. An old wolfer taught me that long ago, also not to think of getting a wolf, think of getting the whole pack. It's not easy, but it can be done. After I take the whole pack, within two weeks there will be another pack running that same territory. There is no shortage of wolves here.