In my own opinion, the only answer that makes sense is “It depends.”
It’s not just that there are a lot of variables, the variables change from shooter to shooter. A few random thoughts:
1. What is “long range” to one shooter might be 150 yards, to another it doesn’t start until somewhere much further downrange. 200 yards is a long ways for my eyes with iron sights, but it’s a chip shot with a scope. 300 yards with a scope seemed like a long ways until I tried it. As a friend said about clay pigeons at 300 yards – they’re “too easy”. And he was right. We backed off to 500 yards and shot 4 pigeons with 7 shots. The misses didn’t miss by much, certainly not enough that a coyote-sized animal would have noticed the difference, let alone larger game.
2. Based on what I have seen at the range during sight-in days, some folks shoot better at 500 yards than others do at 100.
3. Some people use cartridges like the .30-30 that can’t deliver 1500fpe out to 100 yards, others use cartridges that deliver 1500fpe much further. Some people carry laser rage finders, others don’t. Some people use scopes with mil-dot or other drop compensating reticles or target turrets, others don’t. Suitable equipment makes a difference.
4. Some people claim that it isn’t sporting to shoot at long range (whatever that is), ignoring the fact that getting closer is not always an option. I’d rather shoot a standing animal at 500 yards than a running animal at 50. In fact, while I shoot running coyotes, I do not take running shots at game, and haven’t for many years.
5. Choosing not to shoot is always an option, one that responsible shooters often exercise, at ranges near and far. The wind speed may be too high, visibility too poor, the animal may be skylined, whatever. All good reasons not to shoot. When conditions are right, however, why not shoot?
6. The fact that a hunter is prepared to make a 500 yard shot (or a shot at whatever range) does not necessarily mean that the hunter will only take such shots, a fact which seems to escape some people who believe long shots are unethical. Most hunters I know work to get as close as is reasonable and the long shot is the exception not the rule. Other factors being equal, I would prefer to hunt with someone who has prepared for the 500 yard shot rather than someone who has never practiced beyond 100 or 200 yards. One thing about long range shooting at the club, it has helped me at shorter ranges as well.
7. The hunters I know that practice at extended ranges invariably know their equipment better than Joe A. Verage.