Yeah,
I agree with Bob.
Haven't seen the Nosler factories loads here though,
but the best results I've had in my Model 40 are my Nosler 40gr BT reloads with Lil'gun.
I've used the the Hornady 35gr V-Max Factory as a good 100mtr round, albeit a bit light, both in weight, and BC.
I might try that also at 200mtrs with a 1" high at 100mtrs, although with the small targets, and their kill-zones, it's not the ideal.
You'll possibly be zipping either side of a PD's scrawny neck at the shorter distances.
I've found the 45gr SP European loads are pretty tame.
In my mind, you need to get them out the barrel as fast as you can, and the lighter BT's and V-Max's seem ideal.
Funnily enough, I've just tried some 50gr Hornady SP's with Lil'Gun, and was impressed at 100mtrs, although I don't know what speed they were at the muzzle, or their drop at 200.
As you say, I would judge the distance, adjust the scope, and aim in the middle of the target.
Gotta find the most suitable ammo for your rifle first, though ! (Not necessarily the cheapest !!!)
cheers, and good shooting in the Model 40,
Sean in 'Godzone'