The .280 is a favorite of mine and an excellent round. It is everything the .270 is, plus heavier bullets are more common if you reload and like heavy bullets. About the only complaint I have ever heard about the .280 that I can believe is that ammo can be hard to find. That being said, as long as any store carries a reasonable selection of ammo, you should find at least 1 type of .280 ammo. The worst case scenario is you run out of ammo or forget it and have to resort to the local backwoods gas station. In this case, something more common has the edge. Other than that minor issue which is more important to some than others, the .280 is a great round.
-Lou