Not to pirate this thread but...
At least with my 5 1/2 inch fixed sighted SS ROA, it shoots to point of aim with the 45 Colt Conversion and 200gr Cowbow loads, but shoots low with C&B. Have not shot it enough, with C&B 147gr ball, so I can do a Kentucky windage calibration. However, if I could ever find them the heavier C&B conicals may shoot closer to POA. If I were to get another C&B cylinder, I've read of custom cylinders bored out to accept larger doses of BP.
As an aside, I was experiencing many misfires with my ROA using CCI #11 caps, switching to Remington #10 caps has made this C&B revolver 100% on the line.