Wolfpack59,
I realize you don't hanload, but you've picked a pair of cartridges that almost demand it if you want to shoot good quantities of ammo in order to become proficient with the loads that you will use for hunting. If you've got ton's of cash to blow, it's no big deal, buy the highest velocity ammo with the largest bullet that you can find. I don't see any commercial loads for the 10mm that I would use for deer, but that's my preference. The stuff I load provides signifigant performance advantages over anything you can purchase commercially. I shoot a Delta Elite and a Ruger 6.5" Blackhawk for the 10mm, so I don't know how it would apply to your Glock. I've fired the 10mm Glock, but Glock's in general are not my thing. For best performance on game with this cartridge, I'd look to cast bullets, something the Glock isn't the best for with the factory barrel. I'm just a 1911 fan. The Buffalo Bore loads for the .41 look to be about the best you can buy from the ballistics and bullet design standpoint. Like you, I have a new Blackhawk hunter in .41, but have not really delved into what it likes to shoot yet. The 210gr XTP is a good bullet, but it will come apart if you hit heavy bone (shoulders) in my experience with it. I've shot a couple deer with, I'm not satisfied with the performance. I've been loading for the .41 Mag for about 10-11 years, I've never fired a factory round in any of my handguns in this caliber. How does a 300gr cast bullet at 1300 fps sound in that Blackhawk Hunter? I had no problem attaining that in a 7.5" Bisley using loading data from respected sources.
Beyond that, handloading is no big deal as long as you follow the rules. For the cost of 500rds of the ammo you want to shoot, you can EASILY buy a full reloading setup and load your 500rds and have it paid for. This would include both calibers you wish to use in that figure. The commercially available ammo is expensive and you don't just walk into most places an buy any of it, let alone quantities sufficient to get to know the load. There are a lot of people on here who can take the mystery out of handloading for these two round for you. There's no magic in it. It just takes some time an patience. Your shooting will improve many times with just the load development.
Either way you decide to go, you'll have to shoot what is available to see what works best in YOUR guns to see what will be the best for your intended purpose. As I said earlier, I haven't seen any 10mm ammo I'd use for deer hunting.