Went & shot my 22-250 this morning. Was shooting 100 yds. Had shell I loaded with Hornady V-max 55 gr. in new Remington brass, CCI mag. primers, loaded 5 each of 38.1 gr. through 38.5 gr. of H-380 & the 38.5 gr. loads grouped at 1 1/4" at 100 yrds. Beat the heck out of the 3" groups with the Winchester 40 gr. hollow points out of the white box! Seems like its getting better & I'm gonna keep bumping it up & see what happens. If I remember right, I think in the Speer book, 41.0 gr. is the max with H-380 & mag. primers (I don't have the book here in the house with me). I used the Winchester shell to set my seater die, so I guess when I get my best group, I'll need to experiment with the seating depth alittle. One think I can say is this is the most fun I've had in a long time. I'd really like to thank all of you guys for your help & support!!! I'm gonna try some of stimpy's suggestions when I finish with the H-380 (I primed all of my new brass with CCI mag. primers). I bought some Varget & some Winchester primers that I gonna try next. Also got some 50 gr. V-max. Just wish I had more time to soot.