JimG Just a couple of thoughts...
Shooting 100gr. Pyrodex gives 1529 avg fps
100 gr. Goex gives 1546 avg fps
110 gr. Pyrodex gives 1728 avg fps
One of the principles of the PB is that the force of the pressure of the burning powder is suppose to cause the bullet to obturate, force itself up against the lands and grooves. Moving from 100 to 110 might cause a tighter obturation creating a better gas seal also.
To me, and just to me, your velocities seem slow for that weight bullet. I normally do not shoot anything that light, but i have been doing a lot of experimenting with 10mm 200 grain XTP's. I shoot them at 2000 ft/sec with 100 grains of T7.
I am not sure that a wonder wad would aid that much under a powerbelt other than protect the skirt from getting to hot. I shoot a .125 x .510 shot card under 460 grain Bullshop conicals - there is no difference with or without the card in velocity.
I really need to tell you 'I am not a PB fan" so take everything from here on as biased.... I really believe there are far better bullets out there than any of the projectiles you mentioned. In one sentence you mention how easy they are to load - well in todays world there is no reason that a sabot and bullet needs to load hard - snug yes - hard know.... The new polymere sabots of various sizes are so much better than they use to be and seal a lot better.
You do not say what caliber your gun is and I do not know enough about PB's to tell from the weight but i guess I am leaning to it being a 45 cal. rather than a 50 - but it really doesn't matter if you want to try something. If you want to stay with a light bullet that really works, far better than I ever thought, get a box of 10mm 200 grain XTP's and some MMP sabots - either the tan ones for a 45 or the blue ones for a 50. With the blue sabots I can insert them down the barrel with thumb pressure. You will not believe how they shoot and how hard they hit.
I do not have an Optima - but my Omega is close, I normally shoot 260 grain Noslers or 250 grain Gold Dots with MMP HPH-24 sabots. Omega's do have a tight barrel, but even then if the Optima barrel is tighter MMP make a HPH-3p-EZ load sabot that will load very easily - shoots great also. I am shooting these 250/260's with 100 grains of T& also @ 1860 ft./sec.
Just running off the top here - hope some of it is usefull....