Like i said , you will get a lot of different answers on what the ideal cartridge will be. As with any thing when you select a cartridge you compromise. Be it cost, range, availability, performance, etc. You said basically that you wanted a varmint cartridge that will do it all out to 200 yards. If it is fur bearing critter then you want to save hides. I really think that a 17 HMR and a 22 hornet should be limited to no more than 150 yards, period. If you want to limit your shooting to that range then either one would work, but for wood chuck size and up I would limit the 17 HMR to 125 yards and head shots only at that range. This thread has turned to coyotes as the main theme. As far as coyotes are concerned and you are limiting your shooting to 200 yards, any of the center fire cartridges from the 17 Remington up through the 22-250 will work. The 17 Remington and Ruger 204 will in all likelihood not shoot through anything wood chuck size or bigger and will take out any thing smaller with authority out to 400 yards or so. With the 224 caliber guns you will need to be careful about selecting bullets that will not shoot through or will not blow up on the surface to save hides. As you have seen from the above posts there are many differing opinions on what the best hide saver gun is. Again it is a compromise, I guess that is why you are having trouble deciding on which is the "best". There is no best. That is why they sell all of those different calibers and cartridge sizes. I have already stated what my choice would be and why, but that is strictly my choice. You also stated that you "Don't want an oddball/obsolete or wildcat caliber." As far as oddball cartridges are concerned, that is a matter of opinion too. I will not go there. I have always had a love affair with 224 caliber cartridges for my own reasons. But that is just my opinion. Everyone has opinions. Bottom line if you do not consider it oddball ( I have 3 221 Fireballs, a great 200 yd round) then any of the cartridges from the 17 Remington and up will work at the ranges you have stated and probably a little longer. This is your choice, base it on what gun you like. It sounds as if you are not limited on funds for a rifle and you purchase your ammo, not reload. Look at the ammo availability (including bullet types), cost (how much are you going to shoot? 20 rounds a year, 2000 rounds a year?) and the gun you can get the caliber in the gun that is available to you. Base it on those factors. Good luck, you will not go too wrong with any of the center fire stuff.