Very few of us (I'm not one) can handle the loads above what a handi can take. I for one would not like to shoot one above the marlin levels. I pushed 400gr speer bullets to just over 2000 from my BC, and it was filled with lead in the stock. That just plain hurt.
Now with a good recoil pad and faced in a hunting situation, it might be different. but after 4 shots, standing, shooting off hand, I just unloaded the rifle.
More power to you if you can take it.