4350 is an excellent powder in the .30-06 with medium to heavy bullets, excellent in all respects except one. Since it is a coarse grained powder it doesn't always meter well. To get around that, set the measure a bit shy, then drop a metered charge on your scale pan and bring it up to weight with a powder trickler. This slows your loading down a bit but you have that extra confidence from knowing your charges are consistent.