All cartridges have their nitch, and are great within that nitch. The problem is when people try and take them out for game that is outside that nitch. The late and great Frank Glasser, a real outdoors man, could afford the latest and greatest guns the manufactors put out. He got a .220 Swift. The .220 was great for Dall Sheep, Caribou, and Moose, in Franks hands. It was murder on Wolves, on out to 300 and 400 hundred yards. Frank thought it was the greatest thing since sliced bread, till he had an up close and personal encounter with a Grizzly. Frank kept pumping rounds into the bear and ducking behind trees, the bear kept getting up and running around the trees to try and get him. After quite a while of dodging the bear and shooting, making hits every shot, it finally ended when the bear laid down and died. Frank decided the .220 Swift no longer met his needs. Now in my openion it was slightly overrated to and by Frank, before the encounter, but not afterwards. The .243/6MM Had a buddy take it Caribou hunting for his daughters to shoot Caribou with. The kids killed two Caribou, one shot each, at under 100 yards. Both girls made neck shots, and the damage was tremendous. Vertually all the neck meat was so blood shot it was lost. The next year the girls were shooting a .308, and told to make boiler room shots.