It's a very weak cartridge. If you want to stop the animals quickly, use something with more velocity, like one of the magnums. I have used it on woodchucks, but gave up because the old wound-o-matic can drill right through the vitals and they just run away. If you do use one, keep the ranges short, like under 50 yards, and use fast, light, reliable expanding bullets, like the 185 grain Hornady XTPs. That may improve things a bit. I've only used 200 grain cast bullets.