FA once offered an interchangeable cylinder in .45 Win. Mag. for their Mdl. 83 .454 Casull, but I doubt that they still do. Frankly, it doesn't make any sense to do so in a revolver. Since the case headspaces on the mouth, it is difficult to apply a heavy enough roll crimp to prevent bullet creep with very heavy loads, without running the danger of the case mouth slipping past the shoulder in the chamber, thereby causing poor ignition, or even worse, dangerously high pressures.
The .50 AE has these same potential problems in a revolver, and in fact is even more potentially problematic, because the case is tapered and can't even be taper crimped well.The .500 WE is also rimless, but belted, with the cartridge headspacing on the belt and thereby overcoming the potential headspacing and crimping problem that is present with the .45 Win. Mag. Some people have intuitively shied away from the WE, fearing or not understanding the precision of the belt, but in actual practice it works very, very well.
Gene, my suggestion to you for a revolver to use from Black Bear on down, while avoiding the mega-guns, would be to select a good .44 Magnum. It can do it all, and do it very well, on game that size.
