Duffy,
Some bullets, such as the Sierra 130 gr', I believe, in .308 caliber are lightly jacketed to operate well at handgun velocities, though obviously from a bottle-necked cartridge. I was told by the technician that this bullet has a thinner jacket for use in the smoother bores that are put into the Xp-100 and the Striker, etc. (the smoother bore is part of the higher cost of these 'handguns') The thinner jacket, obviously, has the potential of opening up easier - at handgun velocities - as well. My point is, pick an appropriate sectional density for your work based upon contact, I would think, with the manufacturers of the bullets. I think Hornady makes an excellent product. I'd look at their website or call them. Same I would think with Sierra, Speer, or Nosler.
For deer, antelope, etc. I'd still go with the lighter sectional densities of those bullets recommended. For bear and larger I'd go with heavier, handgun-designed bullets.
Incidentally, I believe the 130 gr' in the .270 is actually close to a 165 grain in the .308 diameter. That .270 really moves the lead!