I've been meaning to ask, but kept forgetting.
When I first bought my 45 BH, I purchased some Grizzly 260gr jsp, these are hot loads similar to Buffalo Bore. Any way every time I shot them the cylinder locking pin would back out a little after 2 or 3 shots. The only way I noticed it was it would not want to cock again and I noticed that this pin held some little piece of metal back from catching on the firring pin.
It does not do this with milder loads, but it does concern me, and could it have damaged any thing?