What is nice is to find a load in the 22 rimfire range that will shoot to the sights when you are zeroed for a full power hunting load. I used to have one that shot on at 25 when my Savage 24V was zeroed for 174 gr cast full power rounds. It was a 120 Lee cast and 3gr of bullseye. The way I develop a load like this is to load just one each of various combinations and take them to the range and see which one shoots closest to the bull at 25. After I have an idea of where to go, then I start tweaking it. I don't worry a lot about accuracy, since I am only shooting at 25 yds, most loads will shoot minute of grouse head that far, I'm more interested in regulating the load to the sights.
If your rifle is scoped and the scope has a multiplex reticle, you also have the points of the upper and lower posts that you can use as aming points if you are having a hard time comeing up with something that works. And if the scope is a variable, the ends of the posts shoot to different places as the scopes power is changed.
I would start experimenting with blue dot powder. It works in lots of reduced loads. Fillers aren't required. Reciently I have been working up new grouse loads for my rifles using lightweight jacketed rather than cast bullets, because shooting cast bullets and then jacketed hunting loads might affect the accuracy of my hunting load.