Thank you JT.
A niece of mine recently took a large whitetail buck with a 300 Weatherby by magnum, heart shot, 4 inch exit wound. It made a bit over the typical 100 yard dash before expiring, and didn't even go down when the bullet impacted.
By contrast I talked in person with two elderly local hunters in the past year, who had tried several rifle calibers in their lifetimes, but had settled on the 35 Remington, both claiming it put game down more reliably quick than than high velocity calibers they had used. One of them took quite a few moose, which is what convinced him.
A 14 year old lad I knew 45 years ago was shot in the face with a 12 guage shotgun point blank. The blast took his ear, nose upper jaw and eye on one side. A monster hole, but the lad never went off his feet. He survived just fine, with years of plastic surgery. But the shotgun is a bit different than single projectile wounds, I believe, in most cases. From a bit farther away, where the shot has a chance to spread and wipe out many organs, their impact is nearly always an instant down if the shot is heavy enough to penetrate to the vital organs.