I like to "bark" squirrel. I true big game hunter in the mid-west forest area, will find grey squirrel annoying. As you sit in your stand, they'll sit 15 feet away and squawk at ya all day long telling the whole forest that they are P.O.'d at you!
So I'll take my .54, sit real nice like, till they come scampering about, and when they hug a branch ya shoot the branch just under the head.
The concussion from the bark exploding near the head usually does the job. No meat ruined. I've done that for so many years that now when squirrel see me with the .54, they just climb down and let me hit'm with a stick. no sense wasting powder!
Now rabbit, that's another story,,,,