The lack of blood trail is why I quit hunting deer with cast bullets and switched to hollow points.
I am hunting with a 45/70 Guide gun. I used to shoot the a 405 grain Cast Performance WLN with a .360" meplat. On deer, I have shot 4 deer and lost 2. The only one that didn't run was shot in the neck. With shoulder shots, they run like hell and don't bleed. I recently switched to the 300 grain Hornady hollow point. I shot a doe in the heart/lung area and it ran about 25 yards, bleeding all the way, until it laid down.
I have a 45 Colt Ruger I plan to hunt with using a 250 grain XTP over 24.2 grains of IMR4227. I guess it is moving around 1300 FPS.