After years of Speer Spitzers, Speer Grand Slams, Nosler Ballistics Tips, Winchester and Remmington Factory loads, and finally Nosler Partitions I have settled on the Partitions as the most reliable one shot kill bullets in .277 caliber x 150 gr. on both whitetailed deer and hogs out to 250 yards from my Winchester Model 70 Classic Featherweight.
Ballistic Tips are more accurate (for me) than Partitions but the exit wound of Partitions is USUALLY about the same size as the enrty wound and the animal never takes another step. Partition wound channel characteristics are generally quite wide across and adjacent to the bullet traverse. In contrast, Ballistic Tips tend to start small and blow away a huge chunck from the off hand side. I have had Ballistic Tips disintegrate on impact with dense bone mass, jacket separation, and lost deer that were mortally wounded, but had the energy to run away.
Finding wounded game on my land and the adjacent State land is no pleasure. Anchoring game is the right thing to do for the least "after the shot" effort. Therefore, a steady rest, shot placement, rifleman accuracy, and bullet performance are critical components for success.
I have compared the results on game taken over 15 hunting seasons. For the last 7 years it has been nothing but Partitions. They eat hogs with regularity too, probably ten to one hogs over deer.