I have shot 25 or so hog with handguns, and you really need to choose a bullet that is good for deep penetration. I shot a hog one time with 41JMP AutoMag using the light 170gr Sierra HP, and the bullet barely got through the shoulder. Luckily the second shot ended up in the spine, or he probably would have gotten away.
I shot another hog on the same hunt with a Wildey 45 Win mag and the Speer 260gr HP didn't fare much better. On the shoulder, it never made it to the other side of the chest cavity.
As for 10mm cal, I use a 6" 40 Super, pushing a 200gr XTP at 1400fps and it always blows clean through side to side. If you choose the 10mm, I wouldn't shoot anything under 180gr and perferably a 200.