Now you think about it - Gunnut 69
Threads are based on being able to keep at least 75 - 85% of the material in the hole to make the threads to hold the screw.
If you use a hand drill and you wobble even just one time, you will remove too much material and the hole is no good. The more times you drill it the bigger the hole gets.
A true hole machined is not done in one pass. You usually have to make at least two holes. the first being the pilot hole and the second to make the hole true and to size. The whole time you want to keep the hole in the same place which means that you want to have the gun mounted in a vise. You want both the gun and the vise to be level with the drill. You want no more than .0005 of run out in the spindle. Something you cannot get from a regular drill press.
Then you need precision drill bits, not the kind you get in home depot - because they are very critical on how your work is going to turn out.
When you change screw sizes, you are also going to have to re-drill the bases to a larger size and might also have to reestablish the taper in the bottom of the scope mount base for the larger screw.
You are going to need a bottle or tube of PINK - small screw Loctite. Not RED or BLUE!
Pink is small screw service removable. The rest of them, once you put it in, you will not get it back out. Loctite is not to be used in place of threads. It will only hold the screw and not the material that the screw holds.
Now let's look at what the screw does.
Machine shop theory tells us that for a 1/4 inch bolt, with a grade 8 fastener, you have to screw that bolt 1/4 of an inch into steel to get it's maximum amount of strength.
For an example if we take a 6/40 screw, which is about a drill size of .1130 or a number 33 drill.
Compare that to a 1/4 -20 bolt that has a drill size of number 7 drill bit or .2010
We are talking something half as big, A M4 screw,having to hold something 100 times it's size, a scope mount and a scope.
Now you look at a M4 - which has a pitch of .7 and a diameter of .157 and uses a drill in English of .1299 or rounded off .130 which is a #19 drill size. We use A #19 is .1285 - because that is the closest size available.
That means on either side of the middle of the hole you have 13 1/2 thousandths of material removed from the original piece when you thread it. If you wobble .010 - the hole is now a .140 and is now 9/64'ths of an inch and no longer has enough material inside of the hole to be able to leave you enough material to thread it and put a M4 screw into it and now you are screwed.
Take it to a gun-shop and let them be liable.
Only one screw has been "screwed" up.
Besides for an M4, he does not need to drill, just tap or even he can use a self tapping screw. This set up will be as strong as the 6-48 it replaces.
I have done it many times because outside of the US, you can't virtually find these screws, taps etc...
In some cases like front sights which are not subject to stress, I just used an M3.5 in place of the 6-48, the diam is OK, the pitch being 0.6 compared to the 0.529 of the 6-48 makes only a few thread engages then it blocks. Not as bad as it sounds as so it holds firm !
The real issue is that it is about time manufacturers give up on this flimsy way of mounting scopes, 4 tiny screws, and use strong dovetails like Sako, CZ and others.
Integrated Weaver base would be the ticket.
BTW: You should go metric, it would make thing so simpler, no fraction, no letter gage and dramatically cut on inventory in drills, taps, screws etc.... All companies that have done it were amazed at the savings which can run as high as 30%
http://ts.nist.gov/WeightsAndMeasures/Metric/mpo_fact.cfm