I'm not sure I understand the question. Energy per grain of powder? Energy per grain of powder in a given time frame? Potential energy per grain? Energy under compression and how much compression? I think the variables are too large to accurately determine energy per grain within the cartridge on firing. Case configuration, primer variances, flash hole size, powder column length, bore diameter of the projectile, bullet weight, crimping or lack of, distance bullet is from lands, tight or loose chamber dimensions, and quite a few other variables influence powder ignition and energy derived from it. I'd hate to depend on any calculations with any accuracy or confidence of interpolated powder charges based on energy levels possible solely. This is asking for trouble with a capital T.