That's what H&R will tell you, but recoil may be more than what you'll want to deal with. The Handi is factory chambered in 500 S&W with a comparable case head size and has a higher SAAMI max average pressure than Ruger level 45-70 loads if that tells ya anything. But few shooters like the recoil associated with even mid level levergun loads, so most stay in the upper trapdoor or lower levergun loads.
A nice Limbsaver pad will take a lot of the bite out of the stouter loads, Limbsaver makes a prefit pad specifically for the synthetic stock, #10018, and several of their prefits fit very close to perfect on the standard wood stock, there's a link in the NEF Centerfire FAQs and Help sticky for those part numbers with pics of them on rifles.
Tim