I was in the same boat--stuck deciding which 22lr for hunting...
Here's what I found.
Ruger 22/45 - Good, accurate, reliable. Thin, uncomfy grip. I love the 1911 angle, but it is MUCH too narrow. Fairly common complaints about pins walking out. Otherwise, a good buy starting around $250 for a HB Blued model.
Ruger MKII/MKIII - A little more $$$ than the 22/45 but much better quality. Accurate and reliable--great shooters, tons of aftermarket support (barrels, triggers, sears, sights, etc). A good choice for sure, with a great reputation.
Smith&Wesson 22a- Cheaply made. Tons of complaints about short buffer life and slides cracking. NOT dry fire safe--chamber peening very common and easily dont with this pistol. Okay accuracy.
Starting at $199, it's cheaper...but I think there are more complaints about durability/reliability with this pistol than any other I researched.
Walther P22- Short barreled version not legal to hunt with in my state (4" minimum length barrel). Accuracy? STINKS! Very small grip. A few complaints about slides cracking, but TONS of complaints about reliability. It seems some get a good one, while many get one that needs a fair amount of work to get to feed and eject reliably.
Would make a fun plinker, but terrible hunting rig. Retail starting about $260
Buckmark (camper)- About $260 retail for the camper. Great shooters, decent trigger. Quality browning piece. Definitely can't go wrong with a buckmark. I would've bought one, but once I added up the options I wanted it was a bit out of my price range.
Sig Mosquito - Just shy of a 4" barrel, so again not legal in my state. Lots of reports about cycling issues (not reliable). Overall, well made but definitely not up to Sigs reputation for reliablility. Starting around $320.
Beretta Neos- Modular design--easy to swap barrels. Integrated weaver rail. Single action trigger avg'ing ~4-4.5lbs. Reputation for flawless reliability...seems most Neos' will eat ANYTHING. Magazines are easy to load (integrated thumb lever) and $10 at CDNN. $199 for "blued" and $250 for Inox stainless.
I ended up with the neos, and I am VERY VERY pleased.
Some were complaining about accuracy due to it's modular design, but I've been able to shoot 1" groups, rested, with iron sights using my 6" Inox Neos. It is every bit as accurable (and a bit more reliable) than my lightly modified Ruger MKII.
My very first 5shot group with this pistol, using Federal Bulk packs from walmart got me a .390" CTC at 7yds with iron sights (offhand, strong side supported). It's only getting better since broken in.
4.5" or 6" models are the same price. I opted for the 6" for the longer sight radius (10 inches!) and I think it looked more attractive. I just ordered a new 4.5" barrel and three more magazines. For a budget level handgun, this thing is amazing...once you get past the looks, that is! I paid 260 OTD for my Stainiless 6" neos, which came with 2 magazines as well (most rimfire handguns only come with one!).
My only complain is the wide front sight blade--but they are easily swapped or filed down which is what I did.
Best of luck!