I started out with an Accumark Weatherby in .338/378 with factory Muzzlebrake. I put a Night Force 4.5X15X50 scope on to start with. Fifth round sheared off the screws to the Leupold base, and scope went flying. Had holes for scope base drilled and re-tapped, using over sized screws. Remounted scope and found out scope is too heavy for recoil. Unable to stop it shifting in rings. Went to a Burris scope. Lighter scope works fine.
As for loads, I am shooting 225gr Nosler Accubonds, in front of IMR 7828. Can't remember the grains of powder right off the top of my head, but is seems like it's 102grs of powder. Anyway it cronies at 3210fps. I'm also loading 200gr Noslers with 105gr of IMR 7828, and 250gr Noslers with 99gr of same powder.