I haven't used it, but I hear that the American Pioneer powder is just a joke, and not even a good joke at that. None of the substitute powders I've tried (Pyrodex and 777) are significantly easier to clean than the real stuff, (all three require soap, water, and 5 minutes plus a light oiling after) and you can't let any of them sit without being cleaned, because they will ALL rust your bore.
I don't know about these new "miracle powders" they're bringing out that can be shot 10,000 times without cleaning, but I'll believe it when I see it.