"Is it safe to just re size the primed 308 into 243 with out depriming them?"
Yes. Nothing will come in contact with the primer IF you just raise the decap/expander rod up a half inch or so.
I agree with jhalcott that it's possible the necks may be too thick but I doubt it, factory chambers are pretty loose and factory cases are pretty thin. The thickening from necking down can be overrated but you do need to check the loaded rounds with a micrometer to make sure. If they are thick, get a neck turner and you will end up with better fitting necks than factory stuff. A case trimmer will square the necks easily.
I can identify any of my cartridges across the room, I don't have to look at the headstamp to know what I'm chambering but doing it yourself is up to you. I have been forming .22-250, 6mm International, .243, .244, 7x57, 270 and .308 from bulk .30-06 for maybe twenty years and have never had a problem of not knowing which ammo was what so that "hazard" is sort of dependant on how much attention you pay to your shooting.
For sure, you can't chamber a .308 in a .243, nor can you "accidentally" reload one case instead of the other without knowing it. If you reload your ammo and then put it in a correctly labeled box you shouldn't have any problem. I sure don't.