This idea keeps cropping up among people who don't really understand why the different sizes are made. They seem to think "well, if I need this shot for this game and that shot for that game, why not just mix the two and be set for anything". The obvious problem with that thinking is that you only have half a load of the proper size. Mixed sizes will work OK so long as the range is short enough for the smaller pellets to be effective, but in that case you don't need the larger pellets. At longer range, where you do need the larger pellets, you only have half a load of them and the smaller pellets don't count at all. Either one or the other alone will be better than the mix. People have been shooting lead pellets at game for several hundred years and about everything imaginable has been tried, if mixed shot sizes were a good idea we would all have been using it. For "mixed bag hunting" I do mix sizes, I load my double with #8s in the improved cylinder barrel and magnum 5s in the full choke barrel.