scout34: I have just re-read a article by Brian Pearce in the Handloader Magazine from 2001 entitled Bullet Behavior. Let me run a couple of quote from the article by you: "A cast bullet of proper design, preferably with a generous flatnose or metplat, can best be described as 'old reliable', as it always penetrates deeply while creating a large, permanent wound channel. This delivers the necessary blow to the nervous system and quickly depletes the blood supply. For these reasons, cast bullets are always a top choice, particularly for larger game".....
"Generally, if we push a 250 gn Keith style bullet to 1,400'/sec, cast fairly hard with a Brindle hardness (Bhn) of 17 or 18, penetration is between 28-36 inches on large game. This will vary depending on bone structure and the type of tissue encountered. For comparison, the 270, 7mm mag or even 30-06, even with super-duper bullets, only penetrates approximately 14-22 inches on similar bone/muscle structure. If we take the same 44 Magnum with a Keith style bullet and decrease the velocity to 1,000'/sec, penetration is reduced, but not by a big margin. If deeper penetration is desired, a heavyweight cast bullet weighing 300-320 grains is the next logical choice.".......
I think you may be able to understand why many of us recommend a 250 gn load at only 1,000'/sec. or slightly better. It gets the job done. HTH. Mikey.