I was wondering about the Caliber choices the folks here make, plus it always makes interesting reading. I recently purchased a new Vaquero, and I took sever days to decide the caliber. I went with the .357 Mag. though I already have Molds (2) , Dies, for a .45 (same is true for the .357) so the expense of new reloading equipment is already covered. My choice was recoil. I started out shooting a Colt Combat Commander .45 automatic when I was 14. (I killed lots of rabbits and a few bushytails with it). Then I got a Liberty model SBH .44Mag. I shot that gun until I could hit those little Catsup packages for McDonalds at 20-25 yards or so with it near every time. (helluva splat). Then I got a Dan Wesson .445 super mag (260 gr .429 with a heavy charge of Imr 4227) . I shot IHMSA matches with it. Until I couldn't stop the trembling in my hand for 2 hours. My other single action currently , is a BH in 41 mag that I load lite rounds (220 gr cast at about 950 fps) for and even they are uncomfortable after 40 or 50 rounds . I suppose that if the new Vaguero was offered in 38-40, thats the round I would have bought despite the trouble it is to reload.
So witht the available choices I picked the .357 mag. I can shoot it alot with no pain in my wrist. it uses 100 grains less lead per shot. So I shoot more per pound of lead and powder, with light loads plently of fun, ammo can be gotten anywhere. In full power form it is as good a defense gun as can be had (last I read a 125 gr JHP from a .357 Mag was rated at 80% one shot stop) except for Big bears and such of course my .41 with full power hard cast would go for that i can take a few of those .
I like the old .45 Colt I just want to shoot more for my $ and enjoy it more. A 255 grain bullet out of medium from SA has got to have some real snap to it even with light loads!