I do believe that gube204 has put it as well as I have heard it put. There is no round that will do all things better that all others, or any cal. that is better for all things. I have been loading my own since 1965 and at present have 3 different .17 cal. rounds, a .204, 6 different .22 cal. rounds and so on. It doesn`t matter what round you shoot shot placement is always critical, you have to put the bullet in the vitals. With lite bullets you must put the bullets through the ribs as you don`t have the nessary penitration for a shot from the rear. I also believe that 300 yrds. with a good flat shooting round is about the max. range most the shooters have the ability and knowledge to shoot well at. I loaded some 110 gr. FNHP for a friends .30-30 so he couls use it on varments, he use 1 on a deer. He put the bullet through the ribs into the heart and it dropped like a rock. BUT, if he would have shot it from the rear the bullet would not have made it to the vitals, and I have taken a lot of deer with the Texas eye ball shot. You need to choose a bullet that is suited to your shot.