A weapon is just like any other tool. There are conditions for which some tools are better suited, than others. I think the choice of the Judge for home defense, depends upon what other weapons you already have at your disposal.
This will be difficult to explain, but In my honest opinion, the Judge is not really optimized as a home defense weapon.
The advantage of the Judge is that is gives you a versatile .410, in a small, transportable and concealable handgun. Obviously, the .45 is already available has a handgun, so you haven't gained anything from this configuration, other than the versatility of using one gun to fire both calibers. Hence, the primary benefit gained from the handgun is the .410.
Based upon the weapon's configuration, the Judge is best suited for those situations where you require concealment, holstered transportability, or operations in confined areas which restrict weapon size. Hence, hidden carry on your person, or when firing from within your car, etc.
However, under most conditions, these requirements do not exist inside your home. Therefore, if you already have a potent handgun in your arsenal, the Judge's .45 doesn't give you an advantage that you don't already have.
If you want to shoot the .410 for home defense (so you don't tear up your house with a 12 ga), then you could just purchase a short barreled shotgun which will provide better accuracy and allow you to add an accessory flashlight, laser sight, etc.
In your home, you don't care about concealment and holstered carry, so if you want to use a shotgun, a short 18" barrelled shotgun will still give you plenty of mobility to maneuver from room to room. In fact, Mossberg makes the model HS410 specifically for home defense (the "HS" stands for "Home Security") and is well worth considering.
My point is to examine the weapons available to you, and tailor your arsenal to suit the conditions in which you will operate. If your arsenal is limited, then the versatility of the Judge can be an advantage. If you already have other suitable weapons at your disposal, then another choice may better fullfill that niche.
Just food for thought.
Hope this helps.