Posum
It could also be the relationship between the position of the cartridge in your shell holder and the die. If the cartridge is not all the way into the shell holder, or if there is a slight misalignment between the ram and the die, then the cartridge case is entering the die at a slight angle. Most dies are not engineered to compensate for this, and as the other posts have pointed out, it makes little difference in hunting accuracy.
Target shooters and varment hunters, who need extreme accuracy at long ranges, have for years been using the seating dies that have a separate sleeve for each caliber. This is almost infinitely adjustable, and provides the run-out control that you are asking about, at least by the reports I have read.