Sounds like you need the services of a gunbuilder with a ballistics engineer on staff. As pointed out, the 270WSM or similar may be inappropriate for the H&R platform, but there are other platforms - you get to make some choices and then give it to the pros to sift through and come up with the 'what ifs' for you to consider. They will also give you the necessary guidelines for your ammunition loading.
These requirements I didn't see when I first read the OP. But, really sounds like what you were looking for - some of this stuff is just a bit beyond what hobby handloaders get involved with.
Graybeard gave you some good scoop there and the nuts and bolts answer to the OP. Having a relationship and having a direct relationship to two very different things and from what I've read here, I don't believe many of us are into the statistical explanation of it all. There is no direct relationship as GB pointed out. It's easy to get into unsafe conditions when you stray beyond the written guidelines by very much. Chronographs can help and can also give you erroneous readings. Each weapon is an individual, which is a big reason the manuals don's all agree on specific charges or specific velocities - that's why they are guides. "We" have to be smart enough to keep ourselves in the safe area. Any time I've gone 'overboard' in my quest for answers, my weapon of inquery has "always" told me it didn't like what I was doing. I've learned to listen to them as well as our experienced collegues.
Some of this you don't find in a book - you see it downrange, or at your shoulder, in your wrists, or in your ears. Recognize it.
My question on pressure has always been, since SAAMI did not manufacture my weapon, and XXX Inc makes it in a 260Rem, a fairly high pressure round, why am I limited to say 3/4's of that pressure because mine happens to be chambered for 6.5x55 or say a 35Remington? What am I missing here? Seems like I don't need to buy another rifle, but to simply upgrade the performance of the cartridge I have to the levels of others in the same action. Response?
Regards,
Sweetwater