I don't think they are easily compared, they are really different animals. The 22-250 can do amazing things, you can launch 40gr bullets at 4,500fps or with the proper twist barrel put 75gr bullets down range with great accuracy at long range. The .204 is nearly a "small cal" round, not quite the class of one of the hot 17's but not bad. The case just does not have the capacity to do what the 22-250 can do, but then you can most likely see the hits with the 204 while you will not see them with the 22-250. I have had a 22-250 and a .223, and now have a 17 Remington and a 17 Remington Fireball. The 204 is some place between the .223 and the 17 Remington, but for brute force it is hard to beat the 22-250 unless you go with the king, the 220 swift. I'm not sure the difference in a .223 and .204 is worth the cost of the ammo or components, it is probably just a matter of what you want to carry to the field. A day of shooting the 22-250 will run you down. 17 Fireball is my favorite, but it doesn't have the zip that a good 17 Remington or 17-223 has. Larry